All functions

Boin-class

The BOIN design as a Cumulative-Cohort Design (CCD) subclass

Ccd-class

An R6 class encapsulating Cumulative-Cohort Designs

Cpe-class

An R6 base class for designs requiring Complete Path Enumeration

Cpe3_3-class

An R6 class encapsulating precalculated CPE for 3+3 design

Crm-class

An R6 class encapsulating CRM models This class wraps the functionality of package dfcrm, adding efficient Rust implementations of some numerical routines.

HyperMTDi-class

An R6 base class for hyperpriors over MTDi distributions

as.data.table(<exact>)

Convert an object of class c('exact','precautionary','simulations') to a data.table

as.data.table(<precautionary>)

Convert an object of class c('precautionary','simulations') to a data.table

cohorts_of_n()

Override cohorts_of_n to include latent toxicity tolerances

crm()

A package-local (as-yet, unexported) test harness adapted from dfcrm::crm().

crmh() crmht() crmht2()

Rust implementation of dfcrm::crmh* integrands

crmh_xo()

Rust implementation of dfcrm::crmh* integrands for w==1 case

exact()

A wrapper function supporting exact simulation of dose-escalation trials.

extend()

Extend an existing simulation, using one of several stopping criteria

format(<safetytab>)

Format a phase 1 trial safety tabulation to show significant digits only

hyper_mtdi_lognormal-class

Hyperprior for lognormal MTDi distributions

mtdi_lognormal-class

A lognormal MTDi distribution

ordinalizer

Ordinalizers

phase1_sim()

Override escalation:::phase1_sim to incorporate latent toxicity tolerances

plan

Plan

plot(<mtdi_distribution>,<ANY>)

Visualize an mtdi_distribution object

plot(<mtdi_generator>,<ANY>)

Visualize n samples from an mtdi_generator object

plot_dutycycle()

Plot duty cycle from performance report on a parallel computation

precautionary-package

Safety Diagnostics for Dose-Escalation Trial Designs

print(<exact>)

Specialize print method for objects of class simulations

print(<hyper>) print(<hyper>)

Specialize print method defined for class simulations

print(<precautionary>)

Specialize print method for objects of class simulations

safety_kable()

Output a kable for a simulation summary of class safetytab

simulate_trials()

Simulate trials defined via package escalation

simulation_function(<u_i>)

Get a function that simulates dose-escalation trials using latent u_i

stop_for_excess_toxicity_empiric()

A supremely faster version of a function from dtpcrm v0.1.1

summary(<exact>)

Summarize an exact treatment of a dose-escalation design

summary(<precautionary>)

Specialize a method defined in package 'escalation' for class 'simulations'

test_draw_samples()

Test performance of draw_samples function

viola_dtp

Complete dose transition pathways (DTP) table for the VIOLA trial.